摘要
D8 /17抗原是风湿热 /风心病 (RF/RHD)病人B淋巴细胞膜表面存在的标志性抗原 ,在心肌、骨骼肌和血管平滑肌等组织中亦有分布 ,并具有种族差异性。在多个国家大量的临床实践中证实 ,D8/17抗原在RF/RHD病人阳性率为 80 %～ 10 0 % ,而在正常人群中阳性率为 10 %～ 2 1% ;且D8/17抗原在风湿活动期含量增加 ,活动控制后则含量下降。D8/17抗原在小舞蹈病及与链球菌感染相关的抽搐症、强迫综合征、孤独症等有高达 80 %～ 90 %的阳性率。D8/17抗原本身的特征尚不清楚。本文详细阐述了其临床应用状况、特征、遗传方式 ,并提出了新的研究设想。
The monoclonal antibody D8/17 against a human B lymphocyte alloantigen is a B cell trait marker of rheumatic fever and rheumatic heart disease (RF/RHD) patients.It was also observed in cardiac muscle,skeletal muscle,and smooth muscle of blood vessels.The expression of D8/17 has the ethnic differences.Numerous countries have reported that D8/17 can be identified in 80% 100% of RF/RHD patients,and in 10% 21% of the healthy subjects.D8/17 identified the highest levels of reactive B cells in patients with active acute rheumatic fever,lower levels of rheumatic heart disease,and markedly reduced percentages of reactive cells were observed in normal control subjects.D8/17 may also serve as a marker for susceptibility among some forms of childhood onset obsessive compulsive disorder and Tourette's syndrome,as well as autism.The characteristic of D8/17 itself isn′t clear yet.This review summarizes its clinical application,own property,genetic mode,and put forward the new research idea.
出处
《心血管病学进展》
CAS
2003年第6期432-436,共5页
Advances in Cardiovascular Diseases
