SARS病人血清心肌同工酶水平分析

Serum Myocardial Isoenzyme Level in SARS Patients

为分析严重急性呼吸综合征(SARS)病人血清肌酸激酶心肌型同工酶(CKMB)的变化,用以发现早期急性心肌损伤,将204名SARS病人按年龄分为7组,选出每人住院期间测得的CKMB最高值,计算每组CKMB异常患者的百分率及每组CKMB的平均值及标准差(x±s),并进行统计学分析。再将204名病人按CKMB是否正常分为2组,统计每组中多个肺叶病变患者的比例。结果CKMB异常的百分率20岁以下组28%,21～30岁组12%,31～40岁组17%,41～50岁组22%,51～60岁组42%,61～70岁组33%,大于70岁组26%;CKMB值按上述顺序依次为(23±11)、(19±16)、(21±15)、(20±10)、(24±15)、(36±26)、(22±11)IU/L。CKMB异常组中多个肺叶病变患者占53%,CKMB正常组为35%。提示部分SARS病人存在急性心肌损害,出现CKMB异常的百分比最高的年龄组为51～60岁组;CKMB平均值最高的年龄组为61～70岁组;CKMB异常组中多个肺叶病变患者明显高于CKMB正常组。

We analyzed the content of phospho creatine kinase myocardial isoenzyme(CK-MB)in the serum of SARS patients in order to find out acute myocardial damage in earlier SARS period.Methods:1)Altogether204patients were divided into7groups by age,and the highest CK-MB level was collected in every patient.The percentage of patients with abnormal CK-MB level were calculated and analyzed statistically.2)The patients then were divided into two groups,namely one group with normal CK-MB level and the other with abnormal level.The percentage of patients with multiple pathological changes in lung lobes was estimated for each group.Results:CK-MB abnormal percentages were:17%in the group aged below20;22%in the group aged between41～50;26%in the group aged between51～60.The average CK-MB levels in turn were(23±11),(19±16),(21±15),(20±10),(24±15),(36±26),and(22±11)IU/L.There were53%patients with pathological changes in many lobes of lung in the abnormal group,and35%in the normal group.Conclusions:Acute myocardial damage exists in part of SARS patients.The highest percentage of CK-MB abnormal level is in the group aged between51～60years old.The highest average CK-MB level is in the group aged between61～70years old.The percentage of patients with multiple pathological changes in lung lobes in the abnormal group is much higher than the normal group.