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肝细胞癌中FHIT基因缺失的临床意义 被引量:2

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摘要 Ohta等[1]于1996年首次发现一种新的候选肿瘤抑制基因FHIT基因在多种肿瘤中均有失活,很可能是一种在肿瘤发生中起重要作用的肿瘤抑制基因[2].HCC的发病率呈上升趋势,其发病机制目前仍在探讨中.本研究通过检测HCC肿瘤组织中FHIT基因缺失情况,探讨HCC中FHIT基因改变的临床意义.
出处 《中华肝胆外科杂志》 CAS CSCD 2003年第11期644-644,647,共2页 Chinese Journal of Hepatobiliary Surgery
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  • 1张思仲.动态突变──一种新的致病遗传机理[J].中华医学遗传学杂志,1996,13(3):129-130. 被引量:3
  • 2Ohta M, Inoue H, Cottieelli MG, et al.The FHIT gene, spanning the chromosome 3p14. 2 fragile site and renal carcinoma- associated t (3 ; 8) breakpoint, is abnormal in digestive tract cancers. Cell,1996, 84: 587-597.
  • 3Chen J, Brevet A, Blanquet S, et al.Control of 5' 5'-dinucleoside triphosphate catabolism by APH1, a saccharomyces cerevisiae analog of human FHIT. J Bacteriol, 1998, 180: 2345-2349.
  • 4Yuan BZ, Keek-Waggoner C, Zimonjic DB, et al. Alterations of the FHIT gene in human hepatocellular carcinoma. Cancer Res, 2000, 60: 1049-1053.

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  • 1夏娟,李秉琦,曾昕,陈谦明,何园,蔡扬.EMS1基因扩增与口腔黏膜癌变的相关研究[J].中华口腔医学杂志,2005,40(2):102-104. 被引量:3
  • 2陈钢,王怡,易继林,李兴睿,刘谨文,沈文状,刘峰.Parkin基因在肝细胞癌中的表达与临床意义[J].中华肝胆外科杂志,2006,12(9):619-621. 被引量:4
  • 3杨卫富,李德春,朱兴国.肝细胞癌病人血清中GSTP1、p16基因启动子甲基化的检测[J].中华肝胆外科杂志,2006,12(10):712-713. 被引量:4
  • 4Vavvas D, Li X, Avruch I, et al. Identification of Norel as a potential Ras effector. J Biol Chem, 1998, 273: 5439-5442.
  • 5Lo KW, Kwong J, Hui AB, et al. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res, 2001, 61:3877-3881.
  • 6Lee MG, Kim HY, Byun DS, et al. Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma. Cancer Res, 2001, 61 : 6688-6692.
  • 7Dammann R, Takahashi T, Pfeifer GP. The CpG island of the novel tumor suppressors gene RASSF1A is intensely methylated in primary small cell lung carcinoma. Oncogene, 2001, 20:3563-3567.
  • 8Dammann R, Yang G, Pfeifer GP, et al. Hypermethylation of the CpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res, 2001, 61 : 3105-3109.
  • 9Kuzmin I, Liu L, Dammann R, et al. Inactivation of RAS Domain Family 1A gene in cervical carcinomas and the role of human papillomavirus infection. Cancer Res, 2003, 63: 1888- 1893.
  • 10Schagdarsurengin U, Wilkens L, Steinemann D, et al. Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. Oncogene, 2003, 22:1866-1871.

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