肺癌手术死亡和术后严重并发症及其风险因子的多因素分析

Operative mortality and major complications and risk factors after lung cancer surgery

目的 调查肺癌病人的手术死亡和术后并发症 ,并评价他们的风险因子。方法 回顾性分析了 5 2 8例手术治疗的肺癌病人的手术死亡和术后严重并发症的情况 ,并通过单因素分析和多因素分析鉴别出他们的风险因子。结果 手术死亡率为 2 .8% ,全肺切除和冠心病是手术死亡的独立风险因子 ,全肺切除、冠心病和FEV1≤ 6 0 %是发生术后严重并发症的独立风险因子。结论 全肺切除是影响手术结果最重要的风险因子 ,手术死亡的主要原因是严重的心肺并发症 。

Objective The purpose of this study is to investigate operative mortality and major complications after lung cancer surgery and to estimate the significance of risk factors. Methods Retrospectively analyzed operative mortality and major complications of 528 patients who underwent lung cancer surgery. The significance of risk factors was assessed by univariate and multivariate analyses. Results The operative mortality was 2.8%.Pneumonectomy and coronary heart disease were the independently significant factors for operative mortality. Pneumonectomy, coronary heart disease and FEV 1<60% were the independently significant factors for postoperative major complications. Conclusion Pneumonectomy was the most important risk factor for outcome after lung cancer surgery. Major cardio puhnonary complications were the main causes of operative death. Prevention and treatment of major cardio pulmonary complications could improve outcome after lung cancer surgery.