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番荔枝内酯抑制线粒体复合物Ⅰ的作用机理 被引量：5

MECHANISMS OF INHIBITION OF MITOCHONDRIAL COMPLEX I BY ANNONACEOUS ACETOGENINS
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摘要 番荔枝内酯是对线粒体复合物Ⅰ具有强烈抑制作用的天然产物,它是一条以含末端γ-内酯环 及四氢呋喃环为主要结构特征的长烷基链化合物。本文简述了番荔枝内酯抑制线粒体复合物Ⅰ的动力 学特征和构效关系以及作为抗癌药物与杀虫剂的应用情况。 Annonaceous acetogenins are the natural products inhibiting strongly mitochondrial complex Ⅰ , which are characterized by a long alkyl chain compounds containing terminal γ-lactone and tetrahydrofuran. This paper reviews the kinetic characterization of mito-chondrial complex Ⅰ inhibited by annonaceous acetogenins and their structural activity relationships, and the applications of annona-ceous acetogenins as anticancer drugs and insecticides.
作者 徐志防 魏孝义
机构地区 中国科学院华南植物研究所
出处 《天然产物研究与开发》 CAS CSCD 2003年第5期476-481,共6页 Natural Product Research and Development
关键词 番荔枝内酯 抑制 线粒体复合物Ⅰ 作用机理 番荔枝科 annonaceous acetogenins mitochondrial complex I structural activity relationships
分类号 Q946.8 [生物学—植物学] Q949.747.3 [生物学—植物学]
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参考文献30

  • 1徐志防,魏孝义,谢海辉,杨仁洲.番荔枝内酯类化合物对肝细胞耗氧呼吸的抑制作用及其构效关系[J].药学学报,2002,37(10):818-820. 被引量：5
  • 2Alali FQ, Liu XX, McLaughlin JL. Annonaceous acetogenins: recent progress. J Nat Prod, 1999, 62 (3) : 504-540.
  • 3Rupprecht JK, Hui YH, McLaughlin JL. Annonaceous acetogenins: a review. J Nat Prod ,1990,53(2) :237-278.
  • 4Zafra-Polo MC, Gonzalez MC, Estornell E, et al. Acetogenins from Annonaceae, inhibitors of mitochondrial complex I. Phytochemistry, 1996,42(2) : 253 -271.
  • 5Londershausen M, Leicht W, Lieb F, et al. Molecular mode of action of annonins. Pestic Sci, 1991,33 (4) : 427-438.
  • 6Degli Esposti M, Ghelli A, Ratta M, et al. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (complex I). Biochem J, 1994,301(1) : 161-167.
  • 7Tonno JR, Gonzalez MC, Cortes D, et al. Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenius. Arch Biochem Biophys , 1999,369(1) :119-126.
  • 8Shimada H,Grutzner JB, Kozlowsld JF, et al. Membrane conformations and their relation to cytotoxicity of asimicin and its analogues. Biochemistry, 1998,37(3) : 854-866.
  • 9Miyoshi H, Ohshima M, Shimada H, et al. Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I. Biochim Biophys Acta,1998, 1365(3) :443-452.
  • 10Degli Esposti M, Ngo A, McMullen GL, et al. The specificity of mitochondrial complex I for ubiquinones. Biochem J,1996,313(1) :327-334.

二级参考文献8

  • 1Miyoshi H, Ohshima M, Shimada H, et al. Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I [J]. Biochim Biophys Acta, 1998,1365(3):443-452.
  • 2Tormo JR, Gonzalez MC, Cortes D, et al. Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins [J]. Arch Biochem Biophys, 1999,369(1):119-126.
  • 3Rupprecht JK, Hui YH, McLaughlin JL. Annonaceous acetogenins: a review [J]. J Nat Prod, 1990,53(2):237-278.
  • 4Zafra-Polo MC, Gonzalez MC, Estornell E, et al. Acetogenins from Annonaceae, inhibitors of mitochondrial complex I [J]. Phytochemistry, 1996,42(2):253-271.
  • 5Alali FQ, Liu XX, McLaughlin JL. Annonaceous acetogenins: recent progress [J]. J Nat Prod, 1999,62(3):504-540.
  • 6Chen Y, Yu DQ. Classification and NMR characteristics of the γ-lactone and THF rings of antitumor bioactive annonaceous acetogenins [J]. Acta Pharm Sin (药学学报), 1998,33(7):553-560.
  • 7Londershausen M, Leicht W, Lieb F, et al. Molecular mode of action of annonons [J]. Pestic Sci, 1991,33(4):427-438.
  • 8Landolt JL, Ahammadsahib KI, Hollingworth RM, et al. Determination of structure-activity relationships of annonaceous acetogenins by inhibition of oxygen uptake in rat liver mitochondria [J]. Chem Biol Interact, 1995,98(1):1-13.

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同被引文献41

引证文献5

二级引证文献14

天然产物研究与开发
2003年 第5期

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