胃肠道恶性肿瘤患者外周血T淋巴细胞rDNA转录活性的监测

Analyses of T-lymphocyte rDNA transcription in peripheral blood of patients with stomach-intestine tract malignant tumor

目的 :初步探讨胃肠肿瘤患者外周血T淋巴细胞rDNA转录活性及其临床意义、治疗效果。方法 :对 48例胃肠道恶性肿瘤患者术前、术后T淋巴细胞rDNA转录活性进行了对比研究。结果 :术前T淋巴细胞rDNA转录活性明显低于术后 ,也明显低于正常对照。结论 :T淋巴细胞rDNA转录活性可以灵敏地反映出恶性肿瘤患者的免疫状态 ,可用于胃肠道恶性肿瘤患者手术的临床监测。

AIM: To examine T-lymphocyte rDNA transcription activity in peripheral blood of patients with gastrointestinal maliganant tumor and to clarify its clinical significance.METHODS: T-lymphocyte rDNA transcription activity in peripheral blood of 48 cases of patients with stomach-intestine tract malignant tumor were measured.RESULTS: Before surgery, the T-lymphocyte rDNA transcviption activity was obviously lower than that after surgery, also lower than that of the normal control( P<0.05 ).CONCLUSION: T-lymphocyte rDNA transcription activity could be used as an indicator of immune state of the patients with malignant tumor. It has an important clinical significance in dealing with the patients with digestive tract malignant tumor. [