摘要
Purpose: To study the clinical manifestations and histopathologic changes of trabeculum after excimer laser trabeculectomy ab interno (ELT), and to investigate the mechanisms of ELT in reducing intraocular pressure.
Methods : ELT was performed on ten rabbit eves and postoperative responses were documented. Comeoscleral tissue samples were harvested consecutively each week until the 5th postoperative week and these samples were examined under light and electrical microscopy.
Results: Mild stimulation signs were present postoperatix'ely in nine of ten eyes, but no serious complications were experienced. Obvious inflammation was observed in one rabbit eye as a result of iris damage during the surgical manipulations. Local kactures on the trabecular meshwork and openings into Schlemm' s canal were detected in all tissue samples under light microscope. Mitochondria were found to be turgescent and dilated like vacuoles and endoplasmic reticula were found to be dilated under electrical microscope in the early postoperative period. Later, all trabecular cells returned normal and no fihroblast cells were ever detected.
Conclusions: Permanent openings through trabecular meshwork into the inner wall of Schlemm's canal can be created with ELT. The outflow resistance of aqueous humor can be reduced with these openings and intraocular pressure can be controlled thereafter. Eye Science 2001; 17:11 ～ 15.
Purpose: To study the clinical manifestations and histopathologic changes of trabeculumafter excimer laser trabeculectomy ab interno (ELT), and to investigate the mechanismsof ELT in reducing intraocular pressure.Methods : ELT was performed on ten rabbit eyes and postoperative responses weredocumented. Comeoscleral tissue samples were harvested consecutively each week untilthe 5th postoperative week and these samples were examined under light and electricalmicroscopy.Results : Mild stimulation signs were present postoperatively in nine of ten eyes, but noserious complications were experienced. Obvious inflammation was observed in onerabbit eye as a result of iris damage during the surgical manipulations. Local fractures onthe trabecular meshwork and openings into Schlemm' s canal were detected in all tissuesamples under light microscope. Mitochondria were found to be turgescent and dilatedlike vacuoles and endoplasmic reticula were found to be dilated under electricalmicroscope in the early postoperative period. Later, all trabecular cells returned normaland no fibroblast cells were ever detected.Conclusions : Permanent openings through trabecular meshwork into the inner wall ofSchlemm's canal can be created with ELT. The outflow resistance of aqueous humor canbe reduced with these openings and intraocular pressure can be controlled thereafter.
