非小细胞肺癌的后程适形放疗疗效

Late course conformal radiotherapy for nonsmall cell lung cancer

目的 探讨后程适形放疗在非小细胞肺癌治疗中的临床价值。方法 回顾分析我院 1999年后程适形放疗的非小细胞肺癌患者 19例。对比同期本院非小细胞肺癌患者常规放疗 2 5例。对后程适形放疗组 (latecourseconformalradiotherapy ,LCCR)和常规放疗组 (conventionalradiotherapy ,CR)进行比较。结果 完全缓解率 (CR)和总有效率 (CR +PR)LCCR组为 :3 1 6%和 89 5 % ;CR组为 8%和 60 %。两组有显著性差异 (P <0 0 5 )。 12月生存率、局部控制率LCCR组为 78 9%、68 4 % ,18月生存率、局部控制率LCCR组为 63 2 %、4 7 4 %。CR组分别为 4 8%、2 4 %和 3 2 %、16%。两组差异有显著性意义。放射性食管炎、放射性气管炎、放射性肺炎及放射性肺纤维化 2个组均无差异。结论 后程适形放疗治疗非小细胞肺癌患者的放射毒性反应与常规放疗相似 ,但疗效优于常规放疗。

Objective To explore the clinical value of late course conformal radiotherapy for NSCLC Methods Nine teen patients with NSCLC treated by late course conformal radiontherapy(LCCR) in 1999 were analysed retrospectively Twenty firve patients with NSCLC treated by conventional radiotherapy (CR) during the same period were chosen as the control Results The complete response rate and overall response rates were 31 6% and 89 5% in LCCR, and 8%, 60% in CR( P <0 05) respectively LCCRimproved 12 and 18-month survival and local control rate as compared to CR There was no significant difference in the acute radiation induced tracheitis, pneumonitis or lung fibrosis between the two groups Conclusion The results from our study has shown that LCCR for NSCLC resulted in better early response rate, survival and local control than CR, in terms of toxic effection LCCR is similar to CR