膦甲酸钠治疗重症肝炎疗效观察

Observation of the therapeutic effects of foscarnet on patients with severe hepatitis

目的 探讨膦甲酸钠治疗重症肝炎的疗效。方法 将１９９９年１２月至２００１年１月收治的４３例重症肝炎，分为两组，Ａ组为对照组在综合疗法上加用促肝细胞生长素治疗，Ｂ组为治疗组在Ａ组疗法上加用膦甲酸钠治疗。结果Ａ组２２例患者中治愈１例，好转１１例，无效１０例。Ｂ组２１例患者中治愈１１例，好转７例，无效３例。Ｂ组乙肝病毒指标ＨＢｅＡｇ阴转率６８．７％，ＨＢＶＤＮＡ阴转率７７．７％，而Ａ组均为零。结论 瞬甲酸钠对乙肝病毒有确切抑制作用，治疗重症肝炎疗效显著。

Objective To evaluate the therapeutic effects of foscarnet in severe hepatitis. Methods Forty -three cases of severe hepatitis were divided into Group A and Group B during December 1999 to January 2001. Group A was the control group, which received synthetic treatment and hepatocyte Growth - promoting Factors. Group B was the treatment group, which received group A treatment and foscarnet. Results One of 21 cases in group A was curative,11 cases improved,10 cases inefficient.In group B,11 cases curative,7 casese improved,3 cases inefficient.In group B,68.7%(11/16) HBeAg and 77.7%(14/18)HBVDNA were converted negative,but both in group A were 0% . Conclusions Foscarnet could inhibit HBV replication and had beneficial therapeutic effects on severe hepatitis.