海南省琼中县高疟区应用磷酸萘酚喹控制疟疾的效果

Observation on the effect of naphthoquine phosphate on the control of malaria in Qiongzhong County, Hainan Province

目的 评估在较大的范围内使用磷酸萘酚喹控制疟疾的效果，为今后该药用于控制疟疾提供依据。方法在季节性抗疟控制传染源的用药上，对春季和秋季抗疟的集体服药村庄，一律使用磷酸萘酚喹一天疗法，代替哌喹＋防Ⅱ＋伯喹两天疗法从首次服药的第七天起，由卫生院防保人员和村医，每隔七天到各村巡诊，发现“四热”病人采血送检，掌握用药前后的疫情动态。结果 据疫情报告统计，２０００年全年“四热”血检率达１０％以上，血检阳性率 ０．６２％、居民带虫率０．０５％、年带虫发病率（ＡＰＩ）１．５‰，与１９９９年对比，分别下降５５．８３％、９３．９３％、３３．７８％，发病村（队）由１９９９年的１８０个减至１０９个，减少３９．４４％，且无明显副反应。结论 琼中县高疟区居民集体服药使用磷酸萘酚喹控制疟疾流行效果较为显著，值得继续应用作进一步的评估。

Objective To evaluate the effect of naphthoquine phosphate massively administered in a relative- ly large areas for the control of malaria and providing basis for malaria control in the future. Methods During the seasonal control of malarial source of infection, naphthoquine phosphate in a oneday course was, instead of the two -day therapy of piperaquine + No Ⅱ malaria tablet + primaquine, exclusively used in the villages practicing mas- sive ding administration in the spring and autumn .7 days after the treatment Case detection tour by the village doc- tors and health workers in the township hospitals was conducted at a interval of 7 days ,and the blood samples were taden from the patients with 'four kinds of fever' in order to monitor the coditions before and after the treatment. Results According the statistical results of infection, the blood examination rate in the year of 2000 was over 10%,the positive rate, parasite carrying rate, annual parasite incidence were 0.62% ,0.05% and 1.52‰,respec- tively ,a reduction of 55.83% ,93.93% and 33.78% ,respectively in comparison with that in 1999;the number of villages with malaria case reduced from 180 in 1999 to 109 in 2000,a drop of 39.44%,and no adverse reactions were observed. Conclusion It showed that the effect of massive drug administration of naphthoquine phosphate in high malarial areas for controlling malaria is significant, safe and worthwhile to be popularizcd.