不同剂量米索前列醇晚孕引产的临床研究

Clinical Effect of Misoprostol of Different Doses for Induced Labor in Late Pregnancy

目的 探讨米索前列醇 (以下简称米索 )晚孕引产的最佳剂量。方法 将 80例晚孕的初产妇 ,随机分成 3组 ,分别给予米索 2 5 μg、5 0 μg、10 0 μg引产。 结果 引产的总成功率、用药至临产的时间等 3组间差异均无显著性。而宫缩异常 (过频、过强 )的发生率 10 0 μg组为 34 8% ,明显高于 2 5 μg组及 5 0 μg的 11 0 %和 8 7% (P <0 0 1)。结论 米索前列醇晚孕引产效果肯定 ,以 2 5 μg剂量最佳 ,母婴更安全。

Objective To study the best dose of misoprostol for labor induction in late pregnancy.Methods 80 patients with indications for labor induction were randomly divided into three groups (with doses of 25μg,50μg,100μg misoprostol), intravaginally every 3 hours until uterine contraction occurred . Results No significant difference was noted in the model of labor and patients of successful labor induction(P>0.05). The incidence of abnormal uterine contraction(tachysystole, overstrength)were 11.5%, 8.7% and 34.8%.Abnormal uterine contraction accurred more frequently in the 100μg misoprostol than other groups (P<0.01).Conclusion 25μg misoprostol is safe and effective for induced labor in late pregnency. =