期刊文献+

消风除湿胶囊对实验性早期肺纤维化基质蛋白的影响 被引量:9

The Affect of XIAOFENGCHUSHI Capsules on the Experimental Pulmonary Fibrosis Stromatin in the Early Stage
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摘要 目的:观察消风除湿胶囊(XFCs)对大鼠早期肺纤维化支气管肺泡灌洗液(BALF)中透明质酸(HA)和层粘连蛋白(LN)含量及肺病理变化的影响;方法:通过气管内灌注博莱霉素(BLM)建立大鼠肺纤维化模型,利用放免法测定 BALF中 HA和 LN含量。结果: XFCS治疗组大鼠 BALF中 HA和 LN含量较模型组明显降低,XFCS减轻了BLM大鼠肺泡炎和肺纤维化的病变程度。结论:XFCS降低BLM大鼠BALF中HA和LN含量,可能是抑制或减轻大鼠肺纤维化发生发展的机制之一。
出处 《甘肃中医》 2001年第2期57-59,共3页 Gansu Journal of Traditional Chinese Medicine
基金 甘肃省自然科技基金资助项目!(25991-A23-065-7)
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参考文献8

  • 1侯杰,戴令娟.特发性肺间质纤维化病人肺组织的免疫组化研究[J].中华结核和呼吸杂志,1993,16(3):144-146. 被引量:24
  • 2Thrall RS,Mccormick JR, Jack RM. et al.Bleomycin-induced pulmonary fibrosis in the rat. Am J Pathol. 1979,75:117
  • 3Szapiel SV,Elson NA, Fulmer JD, et, al.Bleomycin-induced interstial pulmonary disease in the nude,athymic mouse. Am Rev Respir Dis. 1979,120:893
  • 4陈金国.细胞外基质组份研究进展[J].国外医学(生理病理科学与临床分册),1999,19(4):249-251. 被引量:7
  • 5Bjermer L, Lundgren R,Hallgren R.Hyaluronan and type Ⅲ procollagen pepide concentrations in bronchoalvelor lavage fluid in idiopathic pulmonary fibrosis. Throax. 1989,44:126~131
  • 6Nakano T, Iwahashi N, maeda J,et al.Serum laminin P1 in small cell lung cancer: a valuable indicator of distant metastasis?Br J Cancer,1992,65:608
  • 7Nellbadt O,Hallgren R. Hyaluronan (HA)in bronchoalveolar lavage fluid during the development of bleomycinsym bol-in duced alveolitis in the rat. Am Rev Respir Dis 1989,140:1028-1032.
  • 8Singer Ⅱ,Extensive Laminin and basement membrane accumulation occurs at the onset of bleomycin-induced rodent pulmonary fibrosis. Am J Pathol 1986,125

二级参考文献6

  • 1褚宏伟,中华医学杂志,1991年,71卷,87页
  • 2B. Bamber,Robert A. Reife,Harald S. Haugen,C. H. Clegg. Oncostatin M stimulates excessive extracellular matrix accumulation in a transgenic mouse model of connective tissue disease[J] 1998,Journal of Molecular Medicine(1):61~69
  • 3Andreas Faissner. The tenascin gene family in axon growth and guidance[J] 1997,Cell & Tissue Research(2):331~341
  • 4Slawomir M. Wojtowicz-Praga,Robert B. Dickson,Michael J. Hawkins. Matrix metalloproteinase inhibitors[J] 1997,Investigational New Drugs(1):61~75
  • 5H. Kosmehl,A. Berndt,D. Katenkamp. Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects[J] 1996,Virchows Archiv(6):311~322
  • 6Antonio Martinez-Hernandez,Peter S. Amenta. The hepatic extracellular matrix[J] 1993,Virchows Archiv A Pathological Anatomy and Histopathology(1):1~11

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