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Action of Selenium Compounds on the Cellular Metabolism by Microcalorimetry

Action of Selenium Compounds on the Cellular Metabolismby Microcalorimetry
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摘要 A new method is introduced to study the action between biomaterials and organism. By using an LKB- 2277 bioactivity monitor and ampoule method, the fundamental thermogenesis curves of the metabolic process of pk-15 and the toxic effect of three kinds of selenomorpholine compounds on it were studied at 37℃. From the thermogenesis curves, the heat released by pk-15 metabolism was calculated. The results show that the selenium compounds all have toxic action on the metabolism process of pk-15 at the range of experimental concentrations. The sequence of the toxic action of selenium compounds is: Na2SeO3>β- ( N- selenomorpholine) -ethyl phenyike-tone hydrochloride > selenomorpholine. A new method is introduced to study the action between biomaterials and organism. By using an LKB- 2277 bioactivity monitor and ampoule method, the fundamental thermogenesis curves of the metabolic process of pk-15 and the toxic effect of three kinds of selenomorpholine compounds on it were studied at 37℃. From the thermogenesis curves, the heat released by pk-15 metabolism was calculated. The results show that the selenium compounds all have toxic action on the metabolism process of pk-15 at the range of experimental concentrations. The sequence of the toxic action of selenium compounds is: Na2SeO3>β- ( N- selenomorpholine) -ethyl phenyike-tone hydrochloride > selenomorpholine.
出处 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2002年第2期90-92,共3页 武汉理工大学学报(材料科学英文版)
基金 Funded by Natural Science Foundation of China (29973030 and 30170010)
关键词 liver mitochondria METABOLISM TOXICITY MICROCALORIMETRY liver mitochondria metabolism toxicity microcalorimetry
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参考文献3

  • 1Xi Li,Yi Liu,Ruming Zhao,Jun Wu,Xuesong Shen,Songsheng Qu.Microcalorimetric study of Escherichia coli growth inhibited by the selenomorpholine complexes[J].Biological Trace Element Research (-).2000(1-3)
  • 2Buckion G,Russell S J,Beezer A E.Pharmaceutical Calorime-try:A Selective Review.Thermochim[].Air Defense Artillery.1991
  • 3Liu Yi,Li Xi,Qu Songsheng,Shen Ping.Microcalorimetric Inves-tigation of the Toxic Action of Cd2+ on Rhizopus Nigricans Growth[].J Biochem Biophys Methods.2000

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