摘要
目的 介绍累积Meta分析方法及其分析特点。方法 采用3种累计方式进行实例分析并辅以图例说明。结果 按研究年代顺序累积能证实疗效最初具有统计学意义的时间,及大型实验缩窄了估计总体治疗效应值可信区间的长度;按样本大小顺序积累能观察到样本大小对综合结果的影响;按治疗组和对照组疗效差异的大小(AR)累积能观察到随着疗效差异较小研究的加入,综合结果的估计值呈现减小的趋势。结论 累积Meta分析方法较传统Meta分析方法提供更多有价值的信息,是传统Meta分析方法不能取代的方法,但该方法仍然受到发表偏倚的影响。
Objective: To introduce cumulative meta-analysis method and its characteristics in analysis. Methods: 3 ways of accumulation were used to analyze real examples and illustrate with graphs. Results: The time when the significant effectiveness of treatment appears first can be confirmed, and the confidence intervals of treatment effectiveness of total population can be narrowed by accumulation in chronological order. The impact of sample size on the comprehensive results can be observed by accumulation according the sample size. With the entering of small difference group the estimated value of comprehensive results tended to be small can observed accumulative according to the difference between treatment and control groups. Conclusion: Cumulative meta-analysis method can provide more information than traditional meta-analysis method. It can't be substituted by traditional method. However, it is affected by publication bias.
出处
《循证医学》
CSCD
2002年第3期167-171,共5页
The Journal of Evidence-Based Medicine
