乙型肝炎患者肝内HBV抗原表达与肝细胞病变的关系

RELATIONSHIP BETWEEN EXPRESSION OF HBV ANTIGENS AND PATHOLOGY OF LIVER CELLS IN PATIENTS WITH VIRAL HEPATITIS TYPE B

本文用ABC法和单克隆抗体检测139例乙肝患者肝组织内HBsAg和HBcAg。HBcAg阳性89例(64.0％),阳性率随乙肝病变严重程度依次递增,膜型HBsAg可能与疾病严重程度有关。HBcAg阳性68例(48.9％),阳性率以慢活肝最高而HBsAg携带者最低,浆膜型HBcAg可能反映了疾病的活动性。HBsAg和HBcAg的膜表达可能与乙肝肝细胞病变密切相关。

Immunohlstochemical methods,i.e.ABC staining technique,and anti-HBs,anti-HBc monoclonal antibodies were used to demonstrate HBsAg and HBcAg in liver tissue of 139 patients with hepatitis B.HBsAg was detected in 89 out of 139 patients(64.0%).The rate of HBsAg-positive increased with the degree of severity of hepatitis B.The membranous HBsAg might be associated with the degree of severity of the disease.HBcAg was detected in 68 out of 139 patients (48.9%).The rate of HBcAg-positive was highest in chronic active hepatitis and lowest in HBsAg carriers.The cytoplasmicmemb-ranous HBcAg might reflect the activity of hepatitis B.There was a close relationship between the membranous expression of HBsAg and HBcAg with pathological changes of liver cells in hepatitis B patients.