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胃腺癌组织中MVD、VEGF及细胞胀亡检测

Detection of MVD, VEGF, and oncosis in gastric adenocarcinoma
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摘要 目的 :检测胃腺癌组织中微血管密度 (MVD)、血管内皮细胞生长因子 (VEGF)与胀亡。方法 :用免疫组织化学方法检测 4 0例胃腺癌组织中MVD和VEGF的表达 ,用透射电镜检测胃癌细胞的胀亡情况。结果 :4 0例胃癌组织中 ,MVD 9～ 78,平均 (36 .5± 1 6 .5 ) ;1 6例VEGF表达阳性 ,阳性率为 4 0 %。胃癌组织中可出现不同时期的胀亡细胞 ,胀亡指数为 (2 .5 94± 0 .1 5 7)。VEGF的表达与胀亡细胞的发生呈负相关 (P <0 .0 5 )。结论 :胃癌组织中血管形成抑制了细胞胀亡的发生。 Aim: To detect the microvessel density (MVD), VEGF, and oncosis in 40 cases of gastric adenocarcinoma. Methods: MVD and the expression of VEGF in gastric adenocarcinoma tissues were detected by immunostaining, and oncosis was detected using transmission electron microscope. Results: MVD count ranged from 9 to 78 in 40 cases of gastric cancer tissues, averaging 36.5±16.5. The positive rate of VEGF expression in gastric cancer tissues was 40%; oncosis index (OI) was 2.594±0.157 in gastric cancer tissues. The VEGF expression and cell oncosis had a negative correlation in gastric cancer tissues ( P <0.05). Conclusions: Angiogenesis in gastric adenocarcinoma may inhibit the development of cell oncosis.
作者 僧靖静 赵高峰 王公平 杨振 韩立志 卫利民 张斌 李向阳 张谢夫 僧国珍 李惠东 陈奎生 高冬玲 张云汉
机构地区 郑州大学第一附属医院外科 沈丘县人民医院外科 郑州大学第一附属医院病理科
出处 《郑州大学学报（医学版）》 CAS 北大核心 2003年第6期859-861,共3页 Journal of Zhengzhou University(Medical Sciences)
基金 河南省杰出青年科学基金资助项目 0 3 12 0 0 2 3 0 0
关键词 胃肿瘤 腺癌 MVD VEGF 胀亡 gastric neoplasm adenocarcinoma MVD VEGF oncosis
分类号 R735.2 [医药卫生—肿瘤]
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参考文献12

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郑州大学学报（医学版）
2003年 第6期

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