右美沙芬对兔急性脑外伤后脑血流速度的影响

Effects of dextromethorphan on brain flow velocity in rabbits with acute traumatic brain injury

目的 :应用经颅多普勒超声 (TCD)技术研究右美沙芬治疗兔颅脑急性损伤后脑血流速度的变化及其意义。方法 :健康雄性白家兔 2 0只 ,随机分为 2组。A组 (n =1 0 )为脑外伤组 ,B组 (n =1 0 )为脑外伤后右美沙芬治疗组。应用TCD分别测定外伤前、伤后 5min、6h、72h、1 6 8h兔大脑中动脉 (MCA)脑血流速度。观察指标为收缩期血流速度 (vS) ,舒张期血流速度 (vD)和脉动指数 (PI)。结果 :A组伤前、后 5min、1 6 8hvS 与B组比较 ,差异无统计学意义 ;A组伤后 6h、72hvS((39.4 5± 7.5 )cm/s,(4 1 .2 0± 5 .94 )cm/s)与B组 ((5 1 .6 8± 1 0 .32 )cm/s,(5 2 .4 1± 8.5 6 )cm/s)比较差异有统计学意义 (P <0 .0 5 ) ;A组伤前、后 5min、1 6 8hvD 与B组比较 ,差异无统计学意义 ;A组伤后 6h、72hvD((2 6 .33± 3.4 6 )cm/s,(2 5 .84± 5 .6 9)cm/s)与B组 ((33.6 4± 4 .2 7)cm/s ,(34.86± 7.4 8)cm/s)比较差异有统计学意义 (P <0 .0 5 ) ;A组伤前、后 5minPI值与B组比较差异无统计学意义 ,A组伤后 6h、72h、1 6 8hPI(2 .0 6±0 .5 8,2 .2 5± 0 .36 ,1 .5 3± 0 .39)与B组 (1 .2 6± 0 .2 9,1 .38± 0 .2 9,0 .96± 0 .1 7)比较差异有统计学意义 (P <0 .0 5 )。结论 :提示右美沙芬可通过改善脑血流速度、降低脉动指?

Aim: To study the effects of dextromethorphan (DM) on the flow velocity of the middle cerebral artery in the rabbit model with traumatic brain injury. Methods: Twenty adult male rabbits were subjected to a lateral traumatic brain injury and then randomly divided into two groups. Group A (Control group, n =10) was treated with normal saline and group B (treatment group, n =10), with DM (50 mg·kg -1 ·d -1 ) after injury. The cerebral blood velocity of the middle cerebral artery (CBVmca), including v S , v D and PI were detected respectively with transcranial Doppler before injury and 5min, 6 h, 72 h and 168 h after injury. Results: The non-significant differences were as following ( P >0.05): for group A and B, v s before and 5 min, 168 h after injury; for group A and B, v d before and 5 min, 168 h after injury; for group A and B, PI before and 5 min after injury. The significant differences were as following ( P <0.01): for group A and B, v s 6 h and 72 h after injury; for group A and B, v d 6 h and 72 h after injury; for group A and B, PI 6 h, 72 h and 168 h after injury.Conclusions: DM could alleviate the focal ischemic pathological lesions after traumatic brain injury by reducing the PI and increasing the CBV.