生长激素在高龄患者胰十二指肠切除术后的应用

Application of Growth Hormone in Senile Patients after Pancreaticoduodenectomy

目的 探讨重组人生长激素 (rhGH)对高龄胰十二指肠切除术患者的治疗作用。方法 患者 46例 ,分为rhGH治疗组 (n =17)和对照组 (n =2 9)两组 ,术后均给予肠外营养。治疗组应用rhGH ,8u皮下注射 1次 /天 ,共 7d ,于术后观察患者白蛋白、前白蛋白、转铁蛋白及免疫球蛋白等指标的变化 ,同时观察患者术后疲劳综合征的发生情况和平均住院时间。结果 术后rhGH治疗组患者的白蛋白、前白蛋白、转铁蛋白及免疫球蛋白指标均显著优于对照组 ,且患者疲劳综合征也明显轻于对照组 ,住院时间明显缩短。结论 rhGH在高龄患者胰十二指肠切除术后的早期应用 ,可改善氮平衡 ,增加机体免疫功能 ,减少感染并发症的发生率 ,促进术后康复 ,缩短平均住院日 ,降低死亡率 ,提高手术安全性 ,可改善高龄患者术后的生活质量。

Objective To explore the effects of recombinant human growth hormone (rhGH) on senile patients after pancreaticoduodenectomy. Methods Forty-six patients were divided into the therapeutic group (rhGH, n =17) and control group ( n =29) . Both were treated with parenteral nutrition. In the therapeutic group, rhGH (8 u/d) was given hypodermically for 7 days. After operation the levels of albumin, prealbumin, transferrin, and immunoglobulin were measured. Postoperative fatigue syndrome and the average length of stay in hospital were observed too. [WT5”HZ]Results After operation the levels of albumin, prealbumin, transferrin, and immunoglobulin in the therapeutic group were significantly higher than those of control group. The degree of postoperative fatigue syndrome in the therapeutic group was less than that of control group. The average length of stay in hospital was significantly shortened. Conclusion The early application of rhGH in senile patients after pancreaticoduodenectomy can enhance immune function, reduce the incidence of infection, promote the postoperative recovery, shorten the average length of stay in hospital,decrease the mortality, increase the safety of operation and improve the postoperative life quality of senile patients.