体外药盒置入胰腺区域动脉灌注治疗重症急性胰腺炎30例临床分析

Clinical Analysis of Local Arterial Infusion for the Treatment of Severe Acute Pancreatitis (Report of 30 Cases)

目的 探讨一种治疗重症急性胰腺炎 (SAP)的新方法。方法 将 5 9例SAP患者根据是否行选择性区域动脉灌注给药而分成两组 :LAI组为体外药盒置入区域动脉灌注的SAP患者 ,共 3 0例 ;对照组为经外周静脉给药的SAP患者 ,共 2 9例。比较两者的临床指标。结果 LAI组在缓解腹痛、恢复肠功能、减少并发症、缩短抗生素使用时间、降低全身感染的发生率等方面均明显优于对照组。使Ⅱ级SAP患者的死亡率从 66.67%降至 3 5 .71%。结论 采用体外药盒置入胰腺区域动脉持续灌注 ,是早期治疗SAP的新方法。

Objective To investigate a new way for the treatment of severe acute pancreatitis (SAP). Methods The clinical data of 59 cases of SAP were analyzed, and they were divided into two groups: LAI group and control group. In LAI group, 30 cases were treated mainly by local arterial infusion (LAI). In control group, 29 cases were treated by intravenous infusion. Results Compared with control group, the results of LAI group were much better in abdominal pain relief, recovery of intestinal function, reducing the complications, shorter antibiotic-time, decreasing the incidence of secondary systemic infection. The mortality of SAP class Ⅱ in LAI group and control group were 35.71 % and 66.67 % respectively. Conclusion LAI is a new way for the treatment of SAP.