摘要
目的 :观察复方丹参滴丸预防治疗短暂性脑缺血发作 (TIA)的临床疗效及对血浆cAMP、cGMP的影响。方法 :选择 180例TIA病人 ,随机分为 3组 ,均口服给药 ,Ⅰ组 60例 ,每日1次 ,每次 10粒 ;Ⅱ组 60例 ,每日 2次 ,每次 10粒 ;Ⅲ组 60例 ,每日 3次 ,每次 10粒。每例病人均 3个月随访1次 ,共随访 18个月 ,同时采用放射免疫分析法 ,测定 3组血浆中的cAMP、cGMP含量。结果 :3组分别发生卒中的例数为 6例、5例、4例 ,副作用分别为 1例、2例、4例 ,未出现牙龈出血、鼻出血及皮下出血病例 ,无统计学意义 (P >0 .0 5 )。 3组cAMP分别为 2 1.2 2 pm /ml± 3 .94pm /ml、2 2 .5 0pm /ml± 3 .16pm /ml、2 3 .10pm /ml± 7.70pm/ml;cGMP分别为3 .67pm /ml± 1.18pm /ml、4.74pm /ml± 2 .12 pm /ml、4.60 pm/ml±0 .70 pm /ml,3组进行两两比较 ,并与本院正常值比较 ,均无统计学意义(P >0 .0 5 )。结论 :复方丹参滴丸在TIA的二级预防中 ,有肯定的疗效 ,且无明显副作用 ,可作为预防和治疗脑血管疾病的药物之一。
Objective:To observe the clinical therapeutical effectiveness of compound Danshen Dropping Pills(CDDP) in prevention of TIA and detect the effect on the content of cAMP and cGMP in plasma. Methods:180 patients with TIA were randomized into three groups equally. The dosage for each group was 10 pills qd, bid and tid respectively. At the same time, the contents of cAMP and cGMP were measured by redio-immunization. Results:There were 6, 5 and 4 patients who developed stroke respectively. 1, 2, and 4 patients suffered with side-effect respectively. Although it was shown that the effect of larger dosage was better than smaller ones, it was the same case with side-effect. Compared by statistics, no significant difference was found (P>0.05). The content of cAMP was 21.22 pm/ml±3.94 pm/ml, 22.50 pm/ml±3.16 pm/ml and 23.10 pm/ml±7.70 pm/ml respectively, and cGMP, 3.67 pm/ml±1.18 pm/ml, 4.74 pm/ml±2.12 pm/ml and 4.60 pm/ml±0.70 pm/ml Compared in every tow groups and compared with the normal level of our hospital, no significal difference was found either (P>0.05). Conclusion:In the secondary prevention TIA, Compound Danshen Dropping Pills had certain effect and side-effect was not evident, so it could be used in the prevention and treatment in myocardial and cerebral vascular disease.
出处
《中西医结合心脑血管病杂志》
2003年第10期571-573,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease