脲类杀菌剂戊菌隆的合成

The Synthesis of Phenylurea Fungicide,Pencycuron

以对氯氯苄为原料 ,先与六甲基次胺进行胺化反应制得对氯苄胺 ;然后在RaneyNi催化剂存在下 ,在高压釜中与环戊酮进行缩合反应 ,同时加氢还原 ,得到N -对氯苄基 -N -环戊胺 ;最后N -对氯苄基 -N -环戊胺与苯基异氰酸酯在 50℃的甲苯溶液中缩合 ,处理后得到戊菌隆。产品戊菌隆含量 95% ,以对氯氯苄计总收率 67.3 %。

Chlorobenzylamine was prepared by amination of p-chlorobenzylchloride with hexamethylenetetramine.A solution of 4-chlorobenzylamine and cyclopentyltanone were dissolved in ethanol,and were poured in the autoclave,and a mixture was condensed and hydrogenated to give N-4-chlorobenzyl-N-cycopentylamine on the catalyst at 3.5kg/cm 2 H at 40℃. Finally,a toluene solution of N-4-chlorobenzyl-N-cycopentylamine was treated with phenylisocyanate,and heated at 50℃ for 8h affored pencycuron with 95% purity.The total yield was 67.3% based on the starting material of p-chlorobenzylchlorde.