重症监护病房脓毒症患者降钙素原的临床研究

The clinical study of procalcionin of the septic patients in intensive care medicine

目的 探讨血浆降钙素原 (PCT)在重症监护病房 (ICU)脓毒症患者发病过程中的变化及其诊断价值。方法 采用双抗夹心免疫荧光发光法定量分析 36例脓毒症患者血浆中PCT含量和动态变化 ,并与 2 4例非脓毒症患者及 2 0例健康人对照分析。结果 脓毒症患者中首次测定PCT含量显著高于非脓毒症组和对照组 (P <0 0 1)。动态观察发现PCT随着病情好转逐渐降至正常 ,而 11例死亡患者的PCT因病情恶化呈上升趋势。结论 PCT定量分析是一种快速、灵敏的检测手段 ,对于尽早发现脓毒症、判断其病情及预后具有重要价值。

Objective To investigate the value of procalcitonin significance in the early diagnosis of septic patients in intensive care unit(ICU).Methods Plasma PCT and its variables were measured by the immunoluminometric assay in 36 septic patients,and compared with 24 non-septic patients and 20 healthy persons.Results The plasma levels of PCT increased significantly in patients with sepsis (P<0.01),and were gradually decreased to normal level with improvement.The PCT had a trend of inereasement in sepsis patients who cliecl in the end.Conclusion Quantitative analysis of PCT is a rapid and sensitive method in the early diagnosis and prognosis of sepsis.