阿司匹林单用与联用低分子质量肝素对不稳定型心绞痛治疗作用比较

Low-molecular-weight heparin and aspirin versus aspirin alone in unstable angina pectoris.

目的 观察单用阿司匹林和联用低分子质量肝素 (法安明 )治疗不稳定型心绞痛 (UAP)的临床疗效。方法 将 86例UAP患者随机分为对照组 (阿司匹林 )及治疗组 (阿司匹林 +法安明 ) ,疗程为 1周。结果 1周后总有效率 :治疗组为 88 37% ,对照组为 6 7 4 4 % (P <0 0 5 ) ;观察 4周治疗组无 1例发生急性心肌梗死 ,对照组发生 3例 (9 38% ) ;治疗组未发现明显不良反应。结论 在常规治疗基础上加用法安明 ,能更有效地控制心绞痛发作 ,减少心肌梗死发生率。

Objective To compare the effects of low-molecular-weight heparin (LMWH,fragmin) and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina pectoris (UAP).Methods A total of 86 patients with UAP were randomized into a group receiving aspirin (ASP group) a group receiving aspirin plus LMWH (fragmin group) for one week.Results The effective rate was 88.37% in the fragmin group and 67.44% in the aspirin group after one week (P<0.05).No acute myocardial infarction occurred in the treating group.Three cases had acute myocardial infarction in the aspirin group after 4 weeks.No obvious adverse reaction was observed in the fragmin group.Conclusion Treatment with aspirin plus LMWH is more efficient than aspirin alone during the acute stage of UAP.Treatment with LMWH is efficient,safe and convenient.