短期饮水中氟化物限量值的实验研究

RESEARCH ON LIMITED DOSES OF FLUORIDE IN DRINKING WATER FOR A SHORT-PERIOD

氟是人体必需微量元素。饮水氟是人体氟的重要来源,摄氟过量使氟在体内蓄积,可对正常生理功能产生有害影响。为制订我军战时和行军野营条件下短期饮水中氟化物的限量值提供实验依据,参考WHO饮用水水质准则和OECD化学物质毒性试验指南以及外军战时水质标准,进行了水中氟化物亚急性毒理学实验。研究结果报告于后。

For determining the limited doses of fluoride in drinking water for a short-period in wartime, this article reported the results of animal experiment on the effects of different fluoride doses(0.37, 1.12 and 3.37 mg/kg) on S-D rats. The results were as follows: (1) The incisors fluoride concentrations in three experimental groups increased 2.6, 5.7 and 17.7 times respectively more than those of the control groups, The incidence of mottled teeth in rats was related to fluoride intakes. (2) Fluoride excreted in the urine of the 2nd and 3rd experimental groups increased more significantly than those of the Control groups. (3) The fluoride doses given in such an experiment showed no genetic injury and mutation.The results suggested that 2 mg/litre (F^-) is Suitable for F^- limited dose in drinking water for a short-period in wartime, according to 5 litre drinking water/day, consecutively 90 days per capita.