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动物性食品中抗菌药残留对人体肠道菌群影响的安全性评价 被引量：5

Safety Evaluations about Effects of Antimicrobial Drug Residues on Human Gut Flora
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摘要 动物性食品中残留的抗菌药对人体肠道菌群的影响已引起国际关注和重视。本文介绍了美国FDA和一些国际组织对此问题的观点、相关规定和认识过程 。
作者 刘健华 陈杖榴
机构地区 华南农业大学兽医学院
出处 《中国兽药杂志》 2003年第2期33-37,共5页 Chinese Journal of Veterinary Drug
关键词 抗菌药 残留 肠道菌群 安全评价 动物性食品
分类号 TS207.53 [轻工技术与工程—食品科学] S482 [农业科学—农药学]
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参考文献10

  • 1Cerniglia CE, Kotarski S. Evaluation of veterinary drug residues in food for their potential to affect human intestinal microflora[J]. Regul Toxicol Pharmacol, 1999, 29(3): 238-261.
  • 2FDA/CVM. Guideline No. 52. Microbiological testing of antimicrobial drug residues in food[EB/OL]. http ://www. fda.gov/cvm/guidance/guideline52. html. January, 1996.
  • 3Carman RJ ,Woodburn MA. Effects of low levels of ciprofloxacin on a chemostat model of the human colonic microflora[J].Regul Toxicol Pharmacol, 2001,33(3): 276- 284.
  • 4Perrin Guyomard A, Cottin Sylvie, Corpet DE, et al. Evaluation of residual and therapeutic doses of tetracycline in the human - flora - associated (HFA) mice model[J]. Regul Toxicol Pharmacol, 2001, 34(2): 125- 136.
  • 5FDA/CVM. Assessment of the effects of antimicrobial drug residues from food of animal on the human flora[EB/OL]. http://www. fda. gov/cvm/guidance/dguide52. pdf , December19, 2001.
  • 6WHO. Evaluation of certain veterinary drug residues in food[R]. In: Fifty-second Report of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series 893.World Health Organization, Geneva, Switzerland. 2002,3-8.
  • 7WHO. Evaluation of certain veterinary drug residues in food[R]. In: Fifty - fourth Report of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series 900.World Health Organization, Geneva, Switzerland, 2001,17 -22.
  • 8EMEA/CVMP. Background paper to the revision of the CVMP guideline on the safety evaluation of antimicrobial substances regarding the effects on human gut flora [EB/OL]. http://www. emea. eu. int/pdfs/vet/swp/ 02350len. pdf. May 2001.
  • 9EMEA/CVMP. Revised Guideline on the Safety Evaluation of antimicrobial substances regarding the effects on human gut flora[EB/OL]. http://www. emea. eu. int/pdfs/vet/swp/02340len. pdf. 9 January 2002.
  • 10VICH. 9th VICH Steering Committee launches VICH2 and approves more guidelines [EB/OL]. http://vich. eudra. org/pdf/07 2001/pr01051. pdf. 28 June 2001.

同被引文献59

引证文献5

二级引证文献21

中国兽药杂志
2003年 第2期

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