冠状动脉病变积分与血压变异性的相关性研究

Study of the relationship between coronary artery artery score and blood pressure variability

目的 探讨冠状动脉病变积分(CAS)与血压变异性的关系。方法 724例行冠状动脉造影者(包括高血压病患者和血压正常者)。其中男472例,女252例,年龄34～82(60.28±9.44)岁。以标准Judkins法行冠状动脉造影术,计算机定量分析系统(QCA)分析冠状动脉狭窄程度并计算CAS。所有患者行24h动态血压监测。结果 年龄、性别、体重指数、24h收缩压标准差(24hSTDs)、24h最大平均动脉压、升主动脉内径(Ao)、高血压病史、Ⅱ型糖尿病病史、高密度脂蛋白胆固醇均与CAS有显著相关关系。经多因素Iogistic回归分析显示,24hSIDs和Ao与CAS呈显著正相关。结论 24hSTDs、Ao与CAS密切相关,是高血压病患者和血压正常者冠心病发生发展的良好的预测指标,并可应用于临床指导冠心病危险人群的早期干预。

Objective To evaluate the relationship between the coronary artery score(CAS)and blood pressure variability. Methods Seven hundred twenty-four patients with or without essential hypertension were performed coronary angiography, 472 male patients, 252 female patients, age 34～82 (60.28±9.44) years old. ABPM were measured in all the patients. Coronary artery angiography were performed in all the patients. The severity of coronary artery lessions was analysed by quantitative computer analysis system(QCA) to acquire CAS. Results Age, sex,BMI,24h SIDs, 24h MAPmax, Ao, the history of essential hypertenion, the history of NIDDM, HDL-C related to CAS significantly. Logistic multivariate analysis showed 24 h STDs and An related to CAS significantly. Conclusion 24 h STDs and Ao related to CAS closely. They were predictors of coronary artery disease in patients with or without essential hypertension and the results could be used in clinical indication.