几种新型苯甲酰基脲类几丁质抑制剂的合成(Ⅰ)

Synthesis of some novel benzoylphenylurea chitin inhibitors (Ⅰ)

以百菌清和卤代苯腈为原料经3～4步反应合成出2类共4个新型苯甲酰基脲类几丁质合成抑制剂6a-c和9a.两条路线的反应条件均温和,产率高.化合物的结构得到IR,MS,1HNMR,13CNMR,19FNMR,HRMS等波谱的证实.

Four novel benzoylphenylurea chitin inhibitor derivatives 6a-c and 9,which belonging to two kind of compounds,have been synthesized from readily available starting material chlorothalonil 4 and halobenzenenitrile 1 via three to four steps.Two synthesis routes have some advantages such as mild temperature conditions,high yields.All the novel benzoylphenylureas compounds were confirmed by spectroscopic methods including IR,1H NMR,13C NMR and HRMS.