抑制移植免疫排斥反应的研究进展

Advances in Suppression of Host Immunorejection Response Against the Allo-and Xeno-grafts

移植免疫排斥反应是制约器官移植成功率的重要原因之一 ,多年来人们研究采用多种方法来克服这种排斥反应。从直接降低MHCⅠ类分子表达的方法、Fas和Fas配体系统、微囊技术。

Host immunorejection is one of the most important reasons to limit the survival rate of allogeneic and xenogeneic tissues.Many approaches have been designed to overcome it for decades.This article will review recent advances in the study of the suppression of host immunorejection against the allo and xeno grafts in many aspects,including reduction of the expression of MHCⅠ,Fas and Fas ligand,microencapsulation and introduction of cytokines and costimulating factor antagonist genes into the grafts,etc.