摘要
目的：研究桂皮酸类化合物咖啡酸和阿魏酸对高血压大鼠的降压作用及作用机理。方法：口服咖啡酸与阿魏酸对ＤＯＣＡ高血压大鼠血压的影响，对ＤＯＣＡ高血压动物血浆ＥＴ－１ 浓度、血压、心血管组织增生及ＥＴ－ １、ｃ－ｆｏｓ、ＨＳＰ７０ ｍＲＮＡ基因表达的影响；对ＥＴ－ １ 引起的正常大鼠血压上升的对抗作用。结果：咖啡酸和阿魏酸静脉注射能降低ＥＴ－ １ 引起的正常大鼠血压上升；咖啡酸和阿魏酸长期口服给药能降低ＤＯＣＡ高血压模型大鼠的血压，对心脏和血管组织增生有明显的抑制作用，可降低血浆中ＥＴ－１ 的浓度，并可减少ＥＴ－１ 引起的ｃ－ｆｏｓ、ＨＳＰ７０ ｍＲＮＡ基因表达的增加。结论： 咖啡酸和阿魏酸可通过拮抗ＥＴ－ １ 的作用降低血压。
AIM The antagonistic effects cinnamic acid compounds caffeic acid and ferulic acid on endothelin-1 (ET-1) biological responses,and the antagonistic mechanism of elevation of blood pressure on ET-1 were in vestigated in DOCA-salt hypertensive and normotensive rats.METHODS Blood pressure body weight,cardiovascular tissues wet weight,gene expression of ET-1,c-fos and HSP70 mRNA,plasma levels of ET-1,and 125 I ET-1 binding with 3T3 cells were determined in DOCA-salt hypertensive rats and nor mofensive rats.RESULTS Intraperitoneal injection of Caffeic acid and ferulic acid could increase the survival time after acute death induced by ET-1,blunt the elevation of blood pressure on normotensive rats markedly by ET-1 intravenously,and dilate the vasoconstriction of isolated aortic rings,blunt the elevation of systolic blood pressure and development of cardiovascular hypertrophy in DOCA-salt hypertensive rats,inhibit gene expression of ET-1,c-fos, HSP70 mRNA and decrease the plasma levels of ET-1.CONCLUSION Caffeic acid and ferulic acid are new non-peptide ET-1 antagonists.
出处
《解放军药学学报》
CAS
1999年第5期1-4,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
国家自然科学基金!资助项目
No.39670886
