国产美罗培南体外抗菌活性及抗生素后效应

ANTIBACTERIAL ACTIVITY AND POSTANTIBIOTIC EFFECTS OF DOMESTIC MEROPENEM

目的：本文拟对比研究国产美罗培南与进口美罗培南、伊米培南／ 西司他丁的体外抗菌活性和抗生素后效应（ＰＡＥｓ）。方法：收集美罗培南临床验证患者分离菌，以ＶＩＴＥＸ 分析仪重新进行鉴定，采用琼脂两倍稀释法测定最低抑菌浓度（ＭＩＣ） ，采用光密度法测定抗生素后效应。结果：国产美罗培南与该药的进口产品以及伊米培南／ 西司他丁的抗菌谱相同，抗菌活性相近。对革兰阴性杆菌和革兰阳性球菌均有比较明显的ＰＡＥｓ，且呈浓度依赖性。结论：国产美罗培南对常见致病菌有强大的抗菌活性，与该药的进口产品及伊米培南／西司他丁相似，对革兰阴性杆菌具有较为显著的ＰＡＥｓ。

AIM The antimicrobial activity and post antibiotic effects(PAEs)of domestic meropenem (MEPM-A),meropenem imported (MEPM-B) and imipenem (IPM/CLT) were compared . METHODS Clinical isolates were identified by VITEK.PAEs of antibiotic were determined by spectrophotometric method and MIC were determined by agar dilution method.RESULTS MEPM-A,MEPM-B and IPM/CLT have the similar antimicrobial spectrum and high antibacterial activity.All the three Carbanpenem antibiotics have marked antimicrobial activity on both gram-positive cocci and Gram-negative bacilli,especially on gram-negative bacilli.MEPM-A showed marked PAEs to gram-positive cocci,gram-negative bacilli;moreover,the PAEs were concentration-dependent.CONCLUSION Similar to MEPM-B and IPM/CLT,MEPM-A has strong antimicrobial activity to clinical isolates.In addition,marked PAEs of the MEPM-A to gram-negative bacteria were showed.