国产哌拉西林/他唑巴坦及4种抗菌药物体外抗菌活性

THE ANTIBACTERIAL ACTIVITY IN VITRO OF DOMESTIC PIPERACILLIN/ TAZOBACTAM AND OTHER FOUR ANTIMICROBIAL AGENTS

目的：对比研究哌拉西林／他唑巴坦（ＴＺＸＬ） 与抗菌药物特治星（ＴＺＸ） 、哌拉西林（ＰＩＰ）、特美汀（ＴＭＴ） 和头孢他啶（ＣＡＺ） 对１５４ 株临床分离菌的体外抗菌活性。方法：采用琼脂平板稀释法测定最低抑菌浓度（ＭＩＣ）。结果：ＴＺＸＬ对革兰阳性球菌敏感率１００％ （３４／３４），抗菌活性与ＴＺＸ、ＴＭＴ一致，强于ＰＩＰ、ＣＡＺ。对革兰阴性杆菌敏感率１００ ％ ，与ＴＭＴ相近，强于ＰＩＰ及ＣＡＺ。尤其对产β－ 内酰胺酶的金黄色葡萄球菌、假单胞菌属仍显示较高的抗菌活性。结论：ＴＺＸＬ与ＴＺＸ的抗菌谱、体外抗菌活性基本一致，与ＴＭＴ作用相似，比ＰＩＰ、ＣＡＺ作用强。

AIM The antibacterial activities in vitro of piperacillin/tazobactam (TZXL)、tazoxin(TZX)、piperacillin(PIP)、timentin(TMT) and ceftazodine(CAZ) against 154 bacterials isolated from clinical patients were investigafed.METHODS MICs were determined by agar dillution method.RESULTS The susceptible rate of TZXL against G + coccus was 100%(34/34),TZXL 、TZX and TMT had the similar antibacterial activities which were higher than those of PIP and CAZ.The susceptible rate of TZXL against G - bacilli was 100%,and it had approximately antibacterial activity with TMT which was higher than PIP and CAZ.It is emphasized that TZXL also showed marked activity against Staphyococcus aureus and Pserdomonas spp.especially to β-lactamase positive strains.CONCLUSION The antimicrobial activities of TZXL and TZX were similor,which were slightly higher than that of TMT,and significantly stronger than those of PIP and CAZ.