复方丹参注射液对银屑病患者血中红细胞指数和脂质过氧化水平的影响

EFFECTS OF FUFANG DAN SHEN INJECTION ON RED CELL INDEXES AND THE LEVEL OF LIPID-PEROXIDATION IN PATIENTS WITH PSORIASIS

目的 :探讨复方丹参注射液对红细胞四项指数及血中MDA、SOD及GSH -PX的影响及银屑病的发病机理。方法 :测定银屑病患者用药前后血中红细胞的四项指数及MDA、SOD、GSH -PX的含量 ,并与健康对照组比较。结果 :银屑病患者红细胞四项指数均有异常 ,以平均红细胞体积 (MCV)和平均红细胞血红蛋白浓度 (MCHC)改变最为显著 (P <0 .0 5 ) ,MCV增大MCHC降低 ,而应用复方丹参注射液治疗后 ,MCV和MCHC值均有所改善 ,而且接近对照组 ;同时我们还发现 ,与健康对照组比较银屑病患者血浆MDA水平升高 ,红细胞SOD、GSH -PX活性下降 ,而且应用复方丹参注射液疗后MDA水平下降 ,SOD、GSH -PX活性升高。结论 :提示银屑病的发病可能是SOD、GDH -PS活性下降 ,而不能有效地清除氧自由基 ,使体内MDA水平升高 ,造成红细胞四项指数异常所致 。

AIM To study the effects of fufang danshen injection on indexes of red cell and malonyldialdehyde(MDA)content,superoxide enzyme(SOD) and glutathione-peroxidase(GSH-PX) activities in patients with psoriasis.METHODS Fourty-five psoriasis patients were treated with Fufang dansen injection,compared with fifty normal subjects.We measured their four indexes of red cell,MDA,SOD and GSH-PX of blood.RESULTS The four indexes of red cell were abnormal in psoriasis patients,especially the levels of mean cell volume (MCV) and mean concentration of hemoglobin(MCHC)(P<0.05).After treated with Fufang danshen,MCV and MCHC of red cell changed obviously,approaching normal levels.The level of MDA in patents increased and the activities of SOD,GSH-PX were decreased.After using Fufang danshen the level of MDA decreased and SOD,GSH-PX were increased(P<0.05).CONCLUSION The degree of abnormal of red cell four indexes,MDA,SOD,and GSH-PX were correlated with the stage of this disease,which suggest that abnormality of indexes of red cell and lipid-peroxidation may play a certain role in the pathogenesis of psoriasis.This maybe used as important reference indexes to judge the severity of the disease and evaluate the therapeutic effect of Fufang danshen.