卡铂白蛋白微球的抗肿瘤活性研究

STUDY OF THE ANTI-TUMOR ACTIVITIES OF CARBOPLATIN-LOADED ALBUMIN MICROSPHERES

目的 :考察卡铂白蛋白微球对小鼠移植肿瘤的抑制作用。方法 :选择二种动物模型 :小鼠前肢腋下接种HepA2 2得到实体瘤模型和腹腔接种HepA2 2得到腹水癌模型。试验分为 3组 :生理盐水组、卡铂注射剂组和卡铂白蛋白微球组 ,分别瘤内和腹腔内注射。结果 :卡铂注射剂和微球剂瘤内注射均显著抑制肿瘤的生长 (P <0 .0 1) ,注射剂的肿瘤生长抑制率为2 9 .2 % ,微球剂的肿瘤生长抑制率为 4 9.6% ,后者明显强于前者 (P <0 .0 1)。注射剂能提高腹水癌小鼠的存活率 ,但不能延长小鼠的存活时间 ;卡铂白蛋白微球剂既可以提高小鼠的存活率 ,又可以延长小鼠的存活时间。结论

AIM To study the anti-tumor activities of carboplatin-loaded albumin microspheres to the graft tumors and ascites in mice.METHODS Two models were used in the experiment: mice with Hep A22 tumor implanted subcutaneously to the oxter of the right forelimb and mice with Hep A22 ascites implanted in the abdomen. Both of the model mice were divided into three groups and were injected with saline, carboplatin injection and carboplatin microspheres respectively.RESULTS Both carboplatin injection and carboplatin microspheres inhibited the growth of the tumor significantly(P<0.01),with the inhibiting effect of the microspheres stronger than carboplatin injection(P<0.01). The percent inhibition of the carboplatin was 29.2%, while that of the microspheres was 49.6%. As to the mice with ascites, carboplatin injection increase the survival rate but did not prolong the survival period, while carboplatin microspheres improved both the survival rate and the survival period.CONCLUSION carboplatin microspheres has better effect in tumor inhibition.