人胎脾细胞IL-2和IL-6的产生及其与NK细胞功能发育的关系

THE PRODUCTION OF IL-2, IL-6 IN RELATION TO THE FUNCTIONAL DEVELOPMENT OF NK CELLS IN HUMAN FETAL SPLEENS

人类胚胎发育时期,脾细胞IL-2和IL-6的产生及其与NK细胞功能发育关系的研究结果表明,胚胎20周龄前IL-2的活性和NK活性细胞基本缺乏,但可分泌低水平的IL-6;随个体发育,IL-2、IL-6的产生和NK细胞活性均逐渐增强,三者间呈直线正相关关系(r>0.86);出生前,IL-6的产生和NK细胞活性显著低于成人组(p<0.01),而IL-2的产生巳达成人水平(p>0.05)。最后,对在胚胎发育过程中IL-2和IL-6的产生,及其与NK细胞功能发育间的关系进行了讨论。

The production of IL-2, IL-6 by fetal splenic mononuclear cells (FSMC) and relationship between them and the ontogenetic development of natural killer cell function were studied in human fetal spleens. As a results, before 20 weeks of gestation, both IL-2 and NK cell activities were not measured, but IL-6 was done. It was found that IL-2, IL-6 and NK cell activities were increased with the gestational age, and shown that there were linear positive correlation between the activities of three ones above (r>0.86). Before the birth, the induced IL-2 activity was the same as adult levels (p>0.05), although both IL-6 production and NK activity in fetal spleens were significantly lower than that in adults (p<0.01). Lastly, the production of IL-2, IL-6 in relation to the functional development of NK cells during the embronic development was discussed