逍遥散对人体神经内分泌免疫系统的影响

Influence of Xiaoyao Powder on Human Nerve-Endocrine-Immune System

目的 观察逍遥丸对神经、内分泌、免疫等多项微观指标的影响 ,以探讨逍遥散证在神经 -内分泌 -免疫系统方面的病理机制。方法 临床所有病例均按 3∶ 1比例随机分为两组 :试验组 (逍遥丸治疗组 )与对照组 (知柏地黄丸组 ) ,疗程为 1个月。实验采用高效色谱仪测定血浆去甲肾上腺素 (NE)、肾上腺素 (E)、多巴胺 (DA)含量 ;采用放免法测定血浆 β -内啡肽 (β EP)、促肾上腺皮质激素 (ACTH)、雌二醇 (E2 )、睾酮 (T) ;采用激光散射比浊法测定血浆免疫球蛋白IgA、IgG。结果 试验组自身治疗前后反应差量 (总疗效 )与对照组自身治疗前后反应差量 (总疗效 )相比 ,β EP、E、DA等指标试验组与对照组的总疗效有非常显著差异 (P <0 0 1)。经逍遥丸治疗后 β EP明显上升 (P <0 0 1) ,E、DA明显下降 (P <0 0 1)。结论 提示 β EP、E。

Objective To observe the influence of Xiaoyao Powder (XP) on some nervous, endocrine and immune criteria in order to investigate the pathologic mechanism of the TCM syndrome represented by XP on the basis of the nerve-endocrine-immune system. Methods All clinical cases were randomly divided into the test group (given XP) and control group (given Zhibaidihuang Pills) in the ratio of 3:1, and the course of the treatment was 1 month. The levels of serumal noradrenaline (NE), epinephrine (E) and dopamine (DA) were measured by HPLC, the levels of serumal β-endorphin (β-EP), ACTH, estradiol (E 2) and testosterone (T) were detected by radioimmunoassay, and the levels of IgA and IgG were detected by laser nephelometry. Results There was a significant difference between the levels of β-EP, E and DA in the test group and those in the control group (P<0.01) before and after the treatment. There was an obvious increase in the level of β-EP (P<0.01) and a obvious decrease in the levels of E and DA (P<0.01) after XP treatment. Conclusion The results suggest that the levels of β-EP, E and DA can reflect some microscopic changes in the TCM syndrome represented by XP.