次声对大鼠海马超微结构的影响

Effects of infrasound on hippocampus ultrastructure of rats

目的探讨 8Hz ,90dB及 13 0dB次声对SD大鼠海马超微结构的影响。方法 60只雄性SD大鼠随机分为实验组和正常对照组。实验组大鼠分别暴露于 8Hz、90dB或 8Hz、13 0dB次声仓中 1、7、14、2 1、2 8、3 5、42天 ,每天 2h。实验结束后即刻麻醉取右侧海马固定后送电镜检查。结果海马超微结构受次声作用 1天即可发生改变 ,且损伤随作用时间延长逐渐加重 ,但后期又有所恢复 ;次声作用早期 ,在作用时间相同情况下 ,90dB较 13 0dB致伤作用弱。结论 8Hz、90dB及 8Hz、13 0dB次声可引起大鼠海马超微结构以变性为主的改变 ,损伤程度与时间呈非线性关系 ;大鼠海马对次声损伤存在一定的适应性。

ObjectiveTo investigate effects of 8Hz 90dB and 8Hz 130dB infrasound on hippocampi ultrastructure of SD rats.Methods60 male SD rats were randomly divided into the control group and experimental group. Rats of experimental group were exposed to 8Hz 90dB or 8Hz 130dB infrasound 2 hours every day for 1, 7, 14, 21, 28, 35 and 42 days. As soon as the exposure finished,the right hippocampus of rat was taken and examined by electron microscopy.ResultsHippocampus ultrastructure of rats was changed after only one day exposure to infrasound and the longer exposure to infrasound, the worse ultrastructure changed. But during the latter period,damages of hippocampus ultrastructure became lighter. Different rules were observed between 90dB and 130dB groups.ConclusionInfrasound of 8Hz 90dB and 8Hz 130dB can make hippocampus ultrastructure of rats damaged mainly as denaturalizations. These changes are nonliner with time, and the hippocampus of rats has adaptability to infrasound.