盐酸关附甲素注射液终止室上性心动过速的疗效

Observation of Guan-fu base A (GFA) hydrochloride injection in treatment of paroxysmal supraventricular tachycardia

目的:观察静脉注射盐酸关附甲素对阵发性室上性心动过速的疗效与安全性。方法:入选在我院急诊科或心内科病房住院的阵发性室上性心动过速患者40例,按4:1的比例,随机分为关附甲素组与普罗帕酮组,按个体化原则给予静脉推注。结果:关附甲素组总有效率为78.1％,平均起效时间为(4.9±3.3)min;普罗帕酮组总有效率87.5％,平均起效时间(8.1±4.6)min。2组患者用药后的血压无明显变化。关附甲素组中3例患者在室上速终止时出现偶发室早,1例患者出现舌麻;普罗帕酮组1例患者出现偶发室早。结论:盐酸关附甲素能有效终止阵发性室上性心动过速,不良反应少。

Objective: To observe the efficacy and safety of GFA hydrochloride injection in treatment of paroxysmal supraventricular tachycardia. Methods: 40 in-patients with paroxysmal supraventricular tachycardia were randomly divided to receive GFA hydrochloride ( n = 32) of propafenone (n = 8) by bolus injection in a dose according to body weight. Results: The total effective rate was 78.1% for GFA hydrochloride injection group and 87.5% for propafenone group. The average time to onset of action was (4.9 ±3.3)min for GFA hydrochloride injection group and (8.1±4.6) min for propafenone group. No significant blood pressure change was observed in both groups. 1 case of tongue numbness and 3 cases of premature ventricular beats occurred in GFA hydrochloride group and 1 case of premature ventricular beats occurred in propafenone group. Conclusion:GFA hydrochloride injection is effective in termination of paroxysmal supraventricular tachycardia.