盐酸乐卡地平治疗原发性高血压的耐受性及疗效

The tolerance and efficacy of lercandipine hydrochloride in treatment of essential hypertension

目的:观察盐酸乐卡地平对轻中度原发性高血压患者的耐受性和降压疗效。方法:采用自身双因素交叉试验法,入选50例患者,停用原来正服用的二氢吡啶类钙通道阻滞剂,1～4周改服盐酸乐卡地平,每次10mg(必要时增加到20mg),qd,5～8周恢复服用入选前的二氢吡啶类钙通道阻滞剂,患者在0,2,4,6和8周来医院就诊,整个临床试验过程中患者可继续应用原合并使用的利尿剂。结果:服用盐酸乐卡地平期间,收缩压在2周和4周时降低分别达1.26,1.45kPa,具有显著统计学意义(P均=0.000);舒张压在2和4周时降低分别达1.13,1.63kPa,具有显著统计学意义(P均=0.000)。评价足踝小腿部水肿的水溢出量在2周和4周时降低分别达28.565,30.185mL,说明没有足踝小腿部水肿发生,具有显著统计学意义(2周P=0.001,4周P=0.000)。心率降低在2周时有统计学显著意义(P=0.011)。结论:盐酸乐卡地平可以明显降低收缩压和舒张压,降压作用可达24h,尤其是通常二氢吡啶类钙通道阻滞剂常见的不良反应如下肢水肿、颜面潮红、头痛和眩晕等发生率很低。

Objective:To observe the tolerance and efficacy of lercandipine hydrochloride (LH) in treatment of essential hypertension (EH). Methods: In the two factor self cross-over study,50 outpatients were enrolled. They were asked to stop dihydropyridine calcium entry blocking agents therapy and to receive once daily 10mg LH during 1 - 4 weeks, and retreated with dihydropyridine calcium entry blocking agent therapy during 5-8 weeks. On 0,2,4,6,8 weeks patients were asked to come to hospital for consultation. Diuretics originally used may be added to the regimen during the whole therapy . Results: After 2 and 4 weeks treatment with LH,the SBP decreased to 1.26kPa and 1.45kPa respectively and the DBF decreased to 1.13kPa and 1. 63kPa respectively. There was significant difference (P<0.000) in both cases as compared with pretreatment data. No edema in feet, ankle and leg occurred during treatment. The heart rate decreased significantly at the end of the second week therapy. Conclusion: LH has significant anti-hypertension effect and its action can be maintained for 24h with very low incidence rate of ADRs,especially the incidence rate of leg edema,flush,headache and dizziness.