枸橼酸西地那非对雄性大鼠性活动能力的影响

Effect of Sildenafil Ciltrate on the Sexual Activities of Male Rats

目的 :为了获得与临床相关的药物动力学资料 ,本实验通过给雄性大鼠枸橼酸西地那非灌胃后观察它们性活动的变化。 方法 :4 0只雄性SD大鼠 ,分成阴性对照组 (蒸馏水 )、枸橼酸西地那非低剂量组 ( 0 .0 8% )、中剂量组( 0 .2 4 % )和高剂量组 ( 0 .72 % )共 4组 ,与雌性大鼠成对合笼 ,观察并记录雄性大鼠捕捉潜伏期、爬高潜伏期、6 0min内捕捉次数和 6 0min内爬高次数。 结果 :与阴性对照组相比 ,西地那非高、中剂量组能极显著性提高雄性大鼠的捕捉次数 ,缩短捕捉潜伏期 (P <0 .0 1) ;高、中、低剂量组均能极显著性提高雄性大鼠的爬高次数 ,缩短爬高潜伏期(P <0 .0 1)。 结论 :西地那非能够显著提高雄性大鼠的性活动能力。

Objective: To obtain related pharmacodynamic data for the clinical experiment by observing the sexual activities of male rats after using sildenafil ciltrate through stomach irrigation. Methods: Forty male Sprague Dawlay rats were distributed into 4 groups with different dosages (control with distilled water, low dosage: 0.08 %, medium dosage: 0.24 % and high dosage: 0.72 %). After the male Sprague Dawlay rats were mated with their female counterparts in pairs, the latent period of chasing, the frequencies of chasing in 60 minutes, the latent period of intercourse and the frequencies of intercourse in 60 minutes were recorded. Results: Compared with the control, the frequencies of chasing were significantly increased and the latent periods of chasing were significantly shortened in both high dosage and medium dosage groups after using sildenafil ( P < 0.01 ); The frequencies of intercourse in 60 minutes were significantly increased and the latent periods of intercourse were significantly shortened in all the groups after the use of sildenafil. Conclusions: The sexual activities of male rats treated with sildenafil were significantly activated.