长期游泳运动对大鼠血浆、胸主动脉内皮素-1的影响

The effects of chronic swimming training on ET-1 protein in plasma and thoracic aorta in rats

目的:探讨不同游泳运动对大鼠血浆及血管ET-1的影响。方法:2月龄雄性SD大鼠随机分为对照组(CV)、运动1h组(6次/周)(E1Y)、运动2h组(6次/周)(E2Y)、运动1h组(3次/周)(E3Y),共进行了14周的无负重游泳。测定了血浆和胸主动脉ET-1的含量;血清SOD、MDA和T-AOC;定期测定大鼠体重。结果:(1)运动各组大鼠体重均低于对照组。(2)运动后血浆ET-1浓度均有升高的趋势,但只有E2Y的差异具有非常显著性;运动后胸主动脉ET-1的变化没有显著性。(3)血浆和血管ET-1与血清SOD/MDA、T-AOC之间并没有相关关系。结论:运动减轻体重,可以降低心血管疾病的危险因素;运动后,血浆ET-1适度升高,可能有助于加强心肌收缩力;未发现ET-1的分泌与机体氧化应激水平之间存在明显的因果关系。

To investigate the effect of different chronic swimming training on endothelin-1 in plasma and thoracic aorta in rats. Methods:2 months old SD male rats were divided into control group and 14-week swimming training groups. Swimming training rats were divided into (one-hour) swimming training per day(6 days/week),two-hour swimming training per day(6 days/week),and one-hour swimming training per day(3 days/week). ET-1 protein in thoracic aorta and plasma,the level of SOD,MDA and T-AOC in serum were determined. Body weights were measured periodically. Results:(1)The body weights significantly lowered in swimming training rats compared with control group. (2)Compared with control group,the concentration of the (plasma) ET-1 increased lightly but there were no significant differences in swimming training groups,except that the difference in E2Y was significant,and the concentration of ET-1 in (thoracic) aorta did not change significantly in swimming training rats. (3)There is no cause-effect relationship between the concentration of ET-1 in thoracic aorta and plasma and the level of SOD,MDA and T-AOC in serum. Conclusions:Swimming training can reduce the body weight of rats,which maybe contribute to lower the dangers of cardiovascular diseases. After swimming training,the concentration of the plasma ET-1 increased moderately,which may contribute to strenthen myocardial constriction. It has not been found that there was cause-effect relationship between ET-1 level and oxidative stress.