泮托拉唑治疗急性上消化道出血疗效观察

Effect of pantoprazole intravenous drip for therapy of acute upper gastrointestinal hemorrhage

目的 :观察静脉滴注泮托拉唑治疗急性上消化道出血的疗效。方法 :将62例病人分为2组 :治疗组38例 ,静脉滴注泮托拉唑40mg,12小时1次 ,持续2～3天 ,出血停止后均予泮托拉唑胶囊40mg,口服 ,1日1次维持。对照组24例 ,静脉滴注雷尼替丁150～200mg,12小时1次 ,持续2～3天 ,出血停止后均予以雷尼替丁300mg ,口服 ,1日1次维持。结果 :治疗组有效率92 1% ,止血时间 (1 6±0 5)天 ,再出血率2 6 % ,明显优于对照组 (分别为66 7 % ,(2 5±0 6)天和20 8% ) ,均P<0 05。结论 :静脉滴注泮托拉唑是治疗急性上消化道出血有效、安全的药物 ,尤其适用于中。

Objective:To observe the effect of pantoprazole for therapy of acute upper gastrointestinal hemorrhage.Methods:62patients were randomly divided into two groups.38patients of pantoprazole therpy group(M31,F7;age41a±s13a)received pantoprazole40mg,iv,gtt,q12h,persisting for2～3d.With pantoprazole capsule of40mg.d -1 to persist after hemorrhage stopped.Ranitidine control group(M19,F5;age43a±14a)received ranitidine150～200mg,iv,gtt,q12h,persisting for2～3d.With ranitidine capsule of300mg.d -1 to persist after hemorrhage stopped.Results:The effective rate of pantoprazole therpy group was92.1%.Hemostasia times were(1.6±0.5)d and re-hemorrhage rate was2.6%.The effective rate and hemstasia times and re-hemorrhage rate of pantoprazole group was significantly better than ranitidine group(effective rate of66.7%,hemstasia times of(2.5±0.6)d and re-hemorrhage rate of2.08%).Conclusion:Pantoprazole intravenous drip for therapy the patients of actue upper gastrointestinal hemorrhage is effective and safe,especially adaption to middle and heavy patients of upper gastrointestinal hemorrhage.