尿微量白蛋白测定对早期诊断糖尿病肾病的价值

THE SIGNIFICANCE OF MICROALBUMINURIA IN EARLY DIAGNOSIS OF DIABETIC NEPHROPATHY

目的 研究尿微量白蛋白测定对早期诊断糖尿病肾病的意义。方法 采用改良免疫凝集比浊法检测12 3例 2型糖尿病患者 2 4小时尿微量白蛋白 (MA)、免疫球蛋白 F(Ig G) ,并与 45例正常人对照。结果 常规尿蛋白正常的 2型糖尿病患者尿 MA和 Ig G明显高于正常对照组 (P<0 .0 1) ,常规尿蛋白异常的 2型糖病患者尿 MA和 Ig G又显著高于常规尿蛋白正常的糖尿病患者 (P<0 .0 1)。结论 尿微量白蛋白及免疫球蛋白

Objective To study the significance of microalbuminuria in early diagnosis of dioabetic nephropathy.Methods The 24-hour urinary microalbumin (MA) and urinary immunoglobulin G (IgG) were measured in 123 patients with type 2 diabetes mellitus,using 45 normal subjects as control.Results Compared with normal subjects,the urinary MA and IgG in type 2 diabetic patients with normal urinary protein increased significantly (P<0.01).The urinary MA and IgG in type 2 diabetic patients with abnormal urinary protein were more elevated than that in type 2 diabetic patients with normal urinary protein (P<0.01).Conclusion Measurement of urinary microalbumin and immunoglobulin G might be used as sensitive markers for early diagnosis of diabetic nephropathy.