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坎地沙坦的药理与临床 被引量:6

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摘要 坎地沙坦环已羰乙酯(candesartan cilexetil,商品名:Atacand)系武田公司开发的一个口服有效的非肽类血管紧张素Ⅱ(A Ⅱ)AT_1受体拮抗剂。于1997年在瑞典首次上市,继而在英、美等国家上市。其结构式如下:
机构地区 卫生部北京医院
出处 《药物不良反应杂志》 2000年第3期202-204,共3页 Adverse Drug Reactions Journal
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  • 1Bauer JH, Reams GP. The angiotensin Ⅱ type Ⅰreceptor antagonists:a new class of antihypertensive drugs. Arch Intern Med, 1995,155:1361.
  • 2Shimizu M, Wang QD, Sjoquist PO, et al. The angiotensin Ⅱ AT1-receptor antagonist eandesartan improves functional recovery and reduces the no-reflow area in reperfused isehemie rat hearts. J Cardiovasc Pharmacol, 1999,34(1):78.
  • 3Gavras H. Update on the clinical pharmacology of candsartan cilexetil. Am J Hytpertens,2000, 13(1 pt 2) :25S.
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  • 6刘淑红.血管紧张素Ⅱ阻滞剂伊贝沙坦和坎地沙坦[J].国外医学:药学分册,1998,25(4):246-246.
  • 7Meineke I, Feltkamp H, Hogemann A, et al.Pharmacokinetics and pharmacodynamics of candesartan after administration of its pro- drug candesartan cilexetil in patients with mild to moderate essential hypertension-a population analysis. Eur J Clin Pharmacol, 1997,53(3-4):221.
  • 8Kulbertus H. Pharma- clinics. The drug of the month. Candesartan. Rev Med Liege, 1999,54(6):557.
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  • 10Zuschke CA, Keys I, Munger MA, et al. Candesartan cilexetil: comparison of once-daily versus twice-daily administration for systemic hypertension. Candesartan Cilexetil Study Investigators. Clin Ther, 1999,21(3): 464.

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