小儿脑瘫与弓形虫感染关系的研究

Study on the Relationship between Infantile Cerebral Palsy and Toxoplasmosis

目的探讨海南小儿不明原因脑瘫与弓形虫感染的关系,为诊治小儿脑瘫提供依据.方法以住院确诊不明原因脑瘫患儿为研究组,体检正常的小儿为对照组,比较两组弓形虫抗体IgG和IgM、循环抗原(CAg)、DNA的四项检测,分析弓形虫感染与脑瘫的关系.结果研究组检测79例脑瘫患儿中,弓形虫阳性33例,感染率为41.8%,对照组检测269例中,弓形虫阳性23例,感染率为8.6%,两组对比差别非常显著(P<0.001).结论弓形虫感染是海南不明原因脑瘫患儿的主要原因之一,对于孕妇、新生儿和婴幼儿的弓形虫感染检测,是防治脑瘫发生的手段之一.

Objective To explore the relationship between unknown infantile cerebral palsy and toxoplasmosis in Hainan Province and offer basis for diagnosis and treatment of infantile cerebral palsy. Methods The admitted infants diagnosed as unkown cerebral palsy were taken as the experimental group and the healthy infants by plysical examination were taken as control. Detection of anti-toxoplasma gondii antibodies of IgG and 1gM, circulating antigens(CAg) and DNA was conducted and the relationship between infantile cerebral palsy and toxoplasmosis were compared and analysed. Results Among the 79 infants with cerebral palsy in the experimental group, 33 infants were detected to be infected with toxoplasma gondii giving an positive rate of 41 .8% ;23 positives were detected out of the 269 infants in the control group with an infective rate of 8.6%. significant difference was observed in the tow groups(P < 0.01) Conclusion The infection with toxoplasma gondii is one of the leading cause resulted in the unknown infantile cerebral palsy in Hainan, the detection of toxoplasmosis in the pregnants, new-borns and babies/infants should be one of the measures in preventing the occurrence of infantile cerebral palsy.