摘要
目的 :观察氧化苦参碱 (OMT)对豚鼠心室肌细胞钠电流的影响。方法 :采用全细胞膜片钳技术。结果 :OMT 0 .1、0 .3和 1mmol/ L对钠电流均呈现不同程度的抑制作用 ,且呈现剂量依赖性。结论 :OMT对钠通道的阻滞作用可能是其抗心律失常的作用机制之一。
? Objective:Effects of oxymatrine on the sodium current were studied .Methods:The whole cell voltage clamp technique was used in isolated ventricular cells of guinea pig.Results:Oxymatrine (0.1,0.3 and 1 mmol/L) showed inhibition to the sodium current in dose dependence.Conclusion:These results indicate that inhibition of oxymatrine to the sodium current may be one of mechanisms of its antiarrhythmic action . 〔
出处
《白求恩医科大学学报》
CAS
CSCD
北大核心
2001年第1期41-42,共2页
Journal of Norman Bethune University of Medical Science
关键词
氧化苦参碱
豚鼠
心室肌细胞
钠电流
膜片钳
oxymatrine
patch clamp
sodium current
guinea pig
ventricular cells
