1[1]Mojsov S,Heinrich G,Wilson IB,et al.Preproglucagon gene expression in pancreas and intestine diversifies at the level of posttranscriptional processing[J].J Biol Chem,1986,261:11880-11889.
2[2]Bell GI,Santerre RF,Mullenbach GT.Hamster preproglucagon contains the sequence of glucagon and two related peptides[J].Nature,1983,302:716-718.
3[3]Herrmaan C,Goke R,Richter G,et al.Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients[J].Digestion,1995,56:117-126.
4[4]Schirra J,Katschinski M,Weidmann C,et al.Gastric emptying and releasing of incretin hormones after glucose ingestion in humans.[J].J Clin Invest,1996,97:92-103.
5[5]Brubaker PL.Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides[J].Endocrinology,1991,128:3175-3182.
6[6]Reberge JN,Brubaker PL.Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop[J].Endocrinology,1993,133(1):233-240.
7[7]Nauck MA,Heimesaat MM,Orskov C,et al.Preserved incretin activity of glucagon-like peptide 1(7～36 amide)but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus[J].J Clin Invest,1993,91:301-307.
8[8]Deacon CF,Nauck MA,Nielsen MT,et al.Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type Ⅱ diabetic patients and in health subjects[J].Diabetes,1995,44:1126-1131.
9[9]Hupe-Sodmann K,McGregor GP,Bribenbaugh R,et al.Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1 (7～36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides[J].Regul Pept,1995,58:149-156.
10[10]Nathan DM,Schreiber E,Fogel H,et al.Insulinotropic action of glucagon-like peptide-1 (7～37) in diabetic and nondiabetic subjects[J].Diabetes Care,1992,15:270-276.
4Nathan DM, Schreiber E, Fogel H, et al. Insuliinotropic action of glucagon-like peptide-1 (7-37) indiabeticandnondiabeticsujects[J]. Diabetes Care,1992,15:270-276.
5Thorens B. Expression cloning of the pancreatic βcell receptor for the gluco-ineretin hormone glucagon-like peptide 1 [J]. Proc Natl Acad Sci USA ,1992,89:8641-8645.
6Widmann C, Dolci W, Thorens B. Internlization and homlologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites[J]. Mol Endo- crinol, 1997,11 : 1094-1102.
7Wang Y, Egan J M, Raygada M, et a l. Glucagon-like peptide-1 af- fects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cell [J]. Endocrinology, 1995,136 :4910-4917.
8Flint A,Raben A, Astrup A,et al. Glucagon-like peptide 1 pro- motes satiety and suppresses energy intake inhumans [J]. J Clin Invest,1998,101:515 -520.
9Nauck MA, Kleine N, Orskou C, et al. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide-1 (7-36) in type 2(non insulin-dependent)diabetic patients[J]. Diabetologia, 1993,36:741-744.
10HolZ GG, kuhltreiber WM, Habener JF . Pancreatic beta-cells are rendered glucose competend by the insulinotropic hormone gluagon-like peptide-1 (7-37) [J]. Nature, 1993,361 : 362-365.
