利培酮与氯氮平治疗首发精神分裂症对认知功能的影响

A comparison of cognitive function in the first-onset schizophrenia treated with risperidone and clozapine

目的 比较利培酮和氯氮平对首发精神分裂症患者认知功能的影响。方法 将符合入组标准的首发精神分裂症患者77例随机分为利培酮组与氯氮平组,分别进行8周系统治疗,用阳性与阴性症状量表(PANSS)、韦氏成人智力量表(WAIS-RC)、数字划销试验(CT)和临床记忆量表(CMS)进行检查,评估其疗效和对认知功能的影响。结果 脱落4例,73例患者在8周治疗后PANSS总分明显下降(P<0.01),两组之间差异无显著性(P>0.05)。利培酮组的WAIS-RC、CT、CMS总分均明显高于氯氮平组,差异有显著性(P<0.05～0.01)。结论 利培酮对首发精神分裂症患者认知功能的影响明显好于氯氮平。

Objective To compare the effects of risperidone and clozapine on cognitive function in the first-onset schizophrenic patients. Methods 77 patients with first-onset schizophrenia were randomly divided into risperidone group and clozapine group for 8 weeks. The therapeutic response and cognitive function were assessed by the positive and negative symptoms scale(PANSS) ,wechsler adult intelligence scale (WAIS), the cancellation test(CT),and the clinical memory scale (CMS). Results The total-score of PANSS was significantly decreased after treatment with risperidone or clozapine(P<0. 01). But no significant differences were found between two groups (P>0. 05). The total score of WAIS,CT and CMS were significantly higher in risperidone group than in clozapine group(P<0. 05-0. 01). Conclusion The study suggests that the effects of risperidone on cognitive function in first-onset schizophrenia are better than that of clozapine