2型糖尿病及肥胖与慢性炎症因子

Chronic inflammatory cytokines: Associations with type 2 diabetes and obesity

慢性炎症反应在2型糖尿病和肥胖发生发展中的作用越来越受到人们的重视。许多炎症因子如C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、血浆纤溶酶原激活物抑制因子1(PAI-1)及白细胞介素6(IL-6)等与糖尿病及其并发症有一定关联。2型糖尿病不仅是一个以高血糖为主要表现的疾病,也是一种炎症性疾病。本文对某些炎症因子与糖尿病和肥胖之间关系的研究进行综述,为临床寻找更有效的诊断、预防和治疗手段提供参考。

Role of chronic inflammation in type 2 diabetes and obesity has been recognized in the past few years. Examples of potent inflammatory cytokines are C-reactive protein (CRP),tumor necrosis factor-α(TNF-α) ,plasminogen activator inhibitor-1 (PAI-1) and interleukin-6 (IL-6). Inflammatory processes may have important roles in the development of type 2 diabetes,obesity and insulin resistance. This article reviewed the relationship between some inflammatory cytokines and diabetes, providing references for clinical diagnosis and treatment.