血管紧张素原基因多态性与2型糖尿病合并高血压的相关研究

Association of angiotensinogen gene polymorphism with hypertension in type 2 diabetic patients

目的探讨血管紧张素原(angiotensinogen, AGT)基因多态性与2型糖尿病合并高血压的关系。方法随机选择2型糖尿病患者240例,分为正常血压组(NBP)和高血压组(HBP),采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测其AGT基因多态性,分析AGT基因型在NBP组和HBP组的分布情况。结果各组AGT基因型的分布频率均呈TT>MT>MM,其中M等位基因在女性2型糖尿病HBP组的频率明显高于NBP组。结论AGT基因的M等位基因与女性2型糖尿病患者的高血压密切相关。

Objective To investigate the relationship between angiotensinogen (AGT) gene polymorphism and hypertension in type 2 diabetic patients. Methods A total of 240 patients with type 2 diabetes mellitus were divided into normotensive and hypertensive groups according to their blood pressure measurement, and their fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein were measured. The AGT genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The distributions of AGT genotypes in normotensive and hypertensive groups were similar, and the frequency of M allele in female hypertensive patients was significantly higher than that in female normotensive patients. Conclusion The M allele of AGT gene is probably related to hypertension in female type 2 diabetic patients.