摘要
目的介绍一种利用L-精氨酸(L-ARG)制作成年大鼠皮肤坏死模型的新方法。方法给大鼠饮水中增加L-ARG,用量为500 mg/kg·b.w.·d,时间1周左右。结果L-ARG 可使50%左右的大鼠皮肤坏死、溃疡面形成。结论一定量的L-ARG可引起成年大鼠皮肤坏死,可用于制作皮肤坏死模型。该方法简捷、成模时间短、成模率高。
A new method of establishing adult rat model of skin necrosis using L-arginine (L-ARG) is described. The adult rats were subjected to 5 to 7-day treatment with L-ARG at the dose of 500 mg/kg·b.w.·d that was dissolved in the drinking water, and skin necrosis was subsequently observed in approximately 50% of the rats. Using L-ARG is simple and efficient to establish animal models of skin necrosis, yielding a high success rate within a relatively shorter period of time.
出处
《第一军医大学学报》
CSCD
北大核心
2003年第11期1222-1223,共2页
Journal of First Military Medical University
基金
广东省医学科学技术研究基金(A1999482)~~
关键词
制作
皮肤坏死
动物模型
大鼠
精氨酸
arginine
skin diseases
necrosis
disease models, animal